Effect of Rosiglitazone, a PPAR-γ Ligand on Haloperidol-Induced Catalepsy
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چکیده
منابع مشابه
Effect of Tribulus terrestris on Haloperidol-induced Catalepsy in Mice
Haloperidol, an antipsychotic drug, leads to the development of a behavioural state called catalepsy, in which the animal is not able to correct an externally imposed posture. In the present study we have attempted to evaluate the anticataleptic effect of Tribulus terrestris on haloperidol-induced catalepsy in albino mice. Mice were allocated to four groups, each group containing six animals. B...
متن کاملPiracetam reverses haloperidol-induced catalepsy in mice
Results: Th e administration of haloperidol (2 mg/kg, IP) resulted in signifi cant catalepsy. Piracetam (in dosages of 50, 100, and 300 mg/kg) given IP at the time of haloperidol administration reduced the duration of catalepsy by 24.4%, 32.3%, and 48.2%, respectively. Piracetam given as a 30-min pretreatment reduced the duration of catalepsy by 59.5%, 72.3%, and 78.2%, respectively. Vinpocetin...
متن کاملEffect of NR-ANX-C (a polyherbal formulation) on haloperidol induced catalepsy in albino mice.
BACKGROUND & OBJECTIVE Use of typical antipsychotics like haloperidol in treatment of schizophrenia is associated with a high incidence of extrapyramidal side effects. In rodents, administration of haloperidol leads to the development of a behavioural state called catalepsy, in which the animal is not able to correct an externally imposed posture. In the present study we evaluated the anticatal...
متن کاملEffect of ethanolic leaf extract of Ocimum sanctum on haloperidol-induced catalepsy in albino mice
Neuroleptic drugs used in the treatment of schizophrenia and other affective disorders are known to produce extrapyramidal side effects. Catalepsy induced by these drugs in Department of Pharmacology, Kasturba Medical College, animals has been used as a model for the extrapyramidal side effects associated with Mangalore 575 001, Karnataka, antipsychotic agents in human beings. In the present st...
متن کاملEffect of Different Drugs Influencing Monoamine Neurotransmission on Haloperidol-Induced Catalepsy in Mice
Results: Catalepsy duration was reduced by the non-selective noradrenaline and serotonin reuptake inhibitors imipramine and amitriptyline (21.1% and 22.3% reduction by 20 mg/kg imipramine and amitriptyline, respectively). Catalepsy duration was increased by the selective serotonin reuptake inhibitors (SSRIs) fluoxetine, fluvoxamine, and citalopram and by the serotonin receptor antagonist and re...
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ژورنال
عنوان ژورنال: CNS Neuroscience & Therapeutics
سال: 2013
ISSN: 1755-5930
DOI: 10.1111/cns.12137